Page 427 - Complete Works of Dr. KCV Volume 1

coordinating mechanisms in both phylogeny and ontogeny. In development, gene induced differentiation must precede organizer activity".)
"There is no good reason to postulate, therefore that either the excitatory or the chemical coordination factor is phylogenetically the more primitive. Both types of coordinating mechanisms probably evolved simultaneously and entirely parallelly and in response to the functional needs of the larger size multicellular character and division of labour within organisms, highly specialized, cooperating nervous endocrine systems became differentiated".
"There appears to have been an evolution of certain essential endocrine sources from tissue possessing a simple nervous or conductive function and located within the central nervous system through an intermediate stage where the cells exhibited their secretary function while still retaining the special conductile ability of nerve cells, to a condition in which the cells have become specialized for endocrine activity alone and form glandular tissues or organs apart from the nervous system."
"And in these instances where the secreting cell bodies are still retained within nervous organs special intracellular conductile means are utilized to convey the secreted product beyond the bounds of the highly specialized 'brain-blood barrier' and into proximity to their own vascular beds. Secondarily, other endocrine organs appear to have developed morphologically, but never physiologically, independent of either direct or indirect regulation by the nervous system".
From Comparative Animal Physiology by Prosser, C. L. and Brown, F. A. W. B. Saunders Co. Philadelphia, 1962.
" ... the integration of endocrine activities is a major function of the central nervous system. The situation of the pituitary just beneath the cephalic brain stem, to which it is attached by the infundibular stalk and portal circulatory channels, enables the basal fore - brain and hypothalamus to bring their influences to bear upon the secretion of trophic hormones by this endocrine 'brain'.
From the Waking Brain by Magoun, H.W. Charles C. Thomas, 1958.